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KMID : 0043319810040010009
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Archives of Pharmacal Research
1981 Volume.4 No. 1 p.9 ~ p.17
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Determination of Ampicillin and Cloxacillin Mixture by NMR
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Shin MH
Park MK/Yu CH/Choi JK
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Abstract
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A simple, accurate and specific NMR procedure is described for the determination of ampicillin and cloxacillin mixtures in injection dosage form and capsules. The solvent was dimethylsulfoxde-d6 and maleic acid was the internal standard. By integrating the peak at 2.68 ppm and 4.57 ppm, cloxaciilin and ampicillin could be determined respectively. The relative proton ratio of ampicillin trihydrate and cloxacillin were 1.038 and 0.950. The coefficients of variation of ampicillin trihydrate and cloxacillin in a few commercial preparation were 1.55% (n = 9), 2.69% (n = 15).
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KEYWORD
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